Six college friends head out for a weekend getaway at a Louisiana bayou estate. But when rogue terrorists launch a missile attack on the Gulf Coast, a new kind of horror is unleashed. Now a biological weapon has infected the entire region with a rabies-like virus that turns the local townspeople into fast-moving, rage-crazed, flesh-chomping hordes. The area is quarantined. The madness is spreading. The carnage is out of control. And for six friends trapped in a nightmare of insane violence, how far will they be forced to go to survive?