When a top-secret weapon falls into mercenary hands, wild-card CIA agent Mason "Mace" Brown (Jessica Chastain) joins forces with rival German agent Marie (Diane Kruger), former MI6 ally and cutting-edge computer specialist Khadijah (Lupita Nyong'o), and skilled Colombian psychologist Graciela (Penelope Cruz) on a lethal mission to retrieve it. The unlikely team must also stay one step ahead of a mysterious woman, Lin Mi Sheng (Bingbing Fan), who is tracking their every move as the action rockets across the globe.