Fred Trolleycar (Paul Lieberstein) struggles with intense; crippling back pain. After an appointment with the highly recommended Dr. Street (Paul Feig); Fred learns his back and neck problems are too complicated for treatment. As he works through the pain at his father's law firm; where he has been a (very) long-term paralegal; Fred meets the beautiful; soon-to-be divorcee; Regan Stearns (Rosemarie Dewitt). The two quickly form a bond; and she suggests he visit an acupuncturist who discovers that Fred has a rather unique talent. The culmination of Fred's stressful work environment; his tense relationship with his father and his feelings for still-married Regan fuel his back's strange song. But as Fred finally begins to find relief for both his chronic pain and his persistent loneliness; he wonders if his problems are more psychological than physical.