Set in the Comanche Nation 300 years ago during 1719, the film follows Naru, a fierce and highly skilled warrior, who has been raised in the shadow of some of the most legendary hunters who roam the Great Plains. So when danger threatens her camp, she sets out to protect her people. The prey she stalks, and ultimately confronts, turns out to be a highly evolved alien with a technologically advanced arsenal, resulting in a vicious and terrifying showdown between the two adversaries.