After Dr. Doofenshmirtz's latest "-inator" scheme accidentally removes the powers of some very well-known Marvel Super Heroes (Spider-Man, Iron Man, Thor, and Hulk), the heroes enter the world of Danville and team up with Phineas and Ferb to relocate their powers, defeat the Marvel Super Villains (Red Skull, MODOK, Whiplash and Venom) - who have also shown up to steal Doofenshmirtz's power-draining technology - and save Danville from ultimate destruction!