Knives and Skin follows the investigation of a young girl's disappearance in a stylized version of a rural Midwest town that hovers just above reality, led by an inexperienced local sheriff. Unusual coping techniques develop among the traumatized small-town residents with each new secret revealed. The ripple of fear and suspicion destroys some relationships and strengthens others. The backdrop of trauma colors quintessential rituals-classrooms, dances, courtship, football games-in which the teenagers experience an accelerated loss of innocence while their parents are forced to confront adulthood failures.