Don Peyote tells the story of Warren Allman (Dan Fogler), an unemployed actor who finally finds a purpose in life after he has an unpleasant encounter with a homeless man who tells him that the end is near. Fueled by vivid apocalyptic dreams, Warren becomes obsessed with 2012 doomsday theories and decides to make a movie about the end of the world while his fiancee is busy planning their wedding.