Based on an inspiring true story, Different Drummers follows the heartwarming yet unlikely friendship of two boys growing up in Washington in the 1960s. When David, who is bound to a wheelchair and growing weaker from muscular dystrophy, accurately foretells the death of his fourth grade teacher, a doubtful Lyle, who has an increasingly high energy level, decides to test the existence of God by attempting to get David to run again. A pact is made, and Lyle soon begins to twist the rules in a desperate attempt to give his friend some of his own excess energy. Along the way, the two boys come face to face with life's most painful truths, and Lyle's question is ultimately answered in a way he never could have imagined.