The Los Angeles County Hospital emergency room and the residency Director Dr. Leanne Rorish (Marcia Gay Harden) cope with a staggering number of patients daily. Known for her high-risk procedures in the trauma area she leads the residents to successfully save patients battling the most tragic circumstances - all with the help of Dr. Ethan Willis (Rob Lowe), Jesse Sallander (Luis Guzman), and Will Campbell (Boris Kodjoe).