Channel Zero: Butcher's Block follows Alice Woods and her schizophrenic sister Zoe who have moved to a small town to start over. On the outskirts of town lies Butcher's Block, a hellish neighborhood where junkies roam and lawlessness abounds. The sisters encounter Joseph Peach and his family, who offer them a place with promise of a world without worry and without illness. The sisters soon find that the cost of living the good life comes at an unimaginable price, and there is a fine line between escaping insanity and embracing true madness.