Henry (Alex Wolff), is a caretaker more than teenager, of himself, his home, but most importantly of his chronically ill single mother (Neve Campbell). His girlfriend (Star Slade) is leaving for college, and his ascetic Jewish relatives and their obligatory condolences frustrate more than comfort. When his mother finally passes, Henry is left without purpose, alone for the first time with a crippling grief, and struggling with the knowledge that he was complicit in his mother's drug-induced death. The only person in his life that isn't placating to his loss is his loud, subversive yet charismatic neighbor Ana (Imogen Poots), who lives across the hall and is trying to kick her own drug habit. He quickly becomes attached to Ana, who fills the void his late mother left, and simultaneously stumbles into the world of opioids, becoming entangled in a web of violence, crime, and addiction.