Hard-drinking, pill-popping, bong-ripping Lou (Natasha Lyonne) and her best friend Sadie (Chloe Sevigny) spend their days adrift in a druggy haze. But one wild night out becomes a bad trip that never ends when Lou wakes up with symptoms of an unexplained, highly abnormal pregnancy. Who-or what-is growing inside her? As her due date approaches with alarming swiftness, the fear, paranoia, and conspiracy theories begin to pile up.