When astrophysicist Dr. Jack Murry disappears without a trace, his children, Meg and Charles Wallace, and neighbor Calvin O'Keefe embark on a cosmic quest to find him. Guided by Mrs. Whatsit, Mrs. Who, and Mrs. Which, the children travel to a distant planet and encounter a society controlled by an evil force. They must trust themselves and each other if they are to rescue Dr. Murry and return home safely.