Longtime friends Mia (Liu), Zoe (O'Connor), Juliet (Otto) and Caitlin (Somerville) try to balance their lives as ambitious corporate power players in New York City with their often-tumultuous personal relationships. Bright and driven, they support each other through rocky marriages, professional crises, kids' recitals and the hunt for the perfect loft. But their ambition comes with a price -- though they consistently outpace their male colleagues and husbands in salary and title, they must always be on the watch for scheming rivals eager to bring them down.